Debbie and Doug are desperate to re-ignite the fire of their once passionate marriage, but their future is uncertain. About to hit rock bottom, they enlist the help of an alternative therapist (Maria Bamford) who claims that the only way to save their relationship from impending death is to take acid in Joshua Tree. When they accidentally take ' way, way, way too much' of this prescribed antidote, Debbie and Doug are transported into a hallucinatory world filled with bizarre and hilarious characters (Larry King and Paul Scheer) who shed a unique light on the problems affecting both their relationship and themselves—forcing them to journey within to learn a sobering lesson in love.